This active mattress replacement system combines alternating pressure and low air loss therapy to support pressure redistribution, shear reduction, and microclimate control. Designed for home or long-term care use, it offers adjustable comfort settings, multiple cycle options, and built-in safety alarms. A foam base and firm perimeter provide stability and support, while deep air cells enhance immersion and comfort. The removable antimicrobial cover is fluid-resistant, low shear, vapor permeable, and machine washable for easy care. It also includes quick-release tubing and a CPR valve for rapid deflation.