This active combination therapy mattress system uses alternating pressure and low air loss to support pressure redistribution, shear reduction, and microclimate control. Designed for home or long-term care use, it features adjustable settings, multiple cycle options, and built-in safety alarms. A deep perimeter system enhances safety and stability, while cell-on-cell construction helps maintain support during power loss. The removable 4-way stretch cover is fluid-resistant, low shear, and vapor permeable for easy care and skin protection. It also includes quick-release tubing and a CPR valve for rapid deflation.